大鼠纹状体中Ca(2+)抑制性腺苷酸活性的昼夜节律。

Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum.

作者信息

Chern Y, Lee E H, Lai H L, Wang H L, Lee Y C, Ching Y H

机构信息

Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC.

出版信息

FEBS Lett. 1996 May 6;385(3):205-8. doi: 10.1016/0014-5793(96)00370-5.

DOI:10.1016/0014-5793(96)00370-5

PMID:8647252

Abstract

In the present study, we demonstrate that the Ca(2+)-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca(2+)-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca(2+)-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

摘要

在本研究中，我们证明纹状体中钙抑制性腺苷酸环化酶（AC）活性呈现每日振荡，峰值出现在10:00左右。还观察到A2a腺苷选择性激动剂诱发的AC活性的昼夜波动。在钙抑制性AC活性达到峰值的时间段内，向纹状体内注射A2a选择性腺苷激动剂或拮抗剂，与在较晚时间段相比，导致的运动活动变化更为显著。纹状体中钙抑制性AC活性的显著昼夜变化似乎导致至少一种神经调质作用的昼夜波动。