Wurster K G, Jonatha W, Knörr-Gärtner H
Geburtshilfe Frauenheilkd. 1979 Mar;39(3):222-7.
Among 1600 pregnancies, in which amniocentesis for prenatal diagnosis had been performed, were 73 cases with previous threatened abortion. In none of these abortion occurred after amniocentesis. 56 children have been born so far. There is evidence for a slight but not statistically significant increase in the number of multifactoral anomalies in this group. This study supports former findings of a higher prematurity incidence after vaginal bleeding in early pregnancy. If amniocentesis took place after imminent abortion, brownish discoloured amniotic fluid has been withdrawn in 53%. This phenomenon probably results from transfer of blood substances from hematomata between uterine wall and amniotic sac. Cultivation of amniotic fluid cells may be impaired by those degradation products, prolonging the cultivation period for an average of 2 days. Special methodological modifications to enhance the success of amniotic fluid cell cultivation in those heavily contaminated specimens are discussed. There seems to be no interference with AFP-estimation. Fetoscopy vision may be impaired.
在1600例进行羊膜穿刺术以进行产前诊断的妊娠中，有73例既往有先兆流产史。这些病例中没有一例在羊膜穿刺术后发生流产。到目前为止，已有56名婴儿出生。有证据表明该组多因素异常的数量略有增加，但无统计学意义。本研究支持先前关于孕早期阴道出血后早产发生率较高的研究结果。如果在即将流产后进行羊膜穿刺术，53%的病例抽出的羊水呈褐色。这种现象可能是由于血液物质从子宫壁和羊膜囊之间的血肿转移所致。这些降解产物可能会损害羊水细胞的培养，使培养期平均延长2天。讨论了在那些严重污染的标本中提高羊水细胞培养成功率的特殊方法改进。似乎对甲胎蛋白估计没有干扰。胎儿镜检查视野可能会受到影响。
