构象受限的促甲状腺激素释放激素类似物：焦谷氨酸区域的一种探针 - Suppr | 超能文献

Conformationally restricted TRH analogs: a probe for the pyroglutamate region.

作者信息

Rutledge L D, Perlman J H, Gershengorn M C, Marshall G R, Moeller K D

机构信息

Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.

出版信息

J Med Chem. 1996 Apr 12;39(8):1571-4. doi: 10.1021/jm960053k.

DOI:10.1021/jm960053k

Abstract

摘要

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Conformationally restricted TRH analogs: a probe for the pyroglutamate region.构象受限的促甲状腺激素释放激素类似物：焦谷氨酸区域的一种探针

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Conformationally restricted TRH analogues: constraining the pyroglutamate region.

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Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.促甲状腺激素释放激素（TRH）中焦谷氨酸和组氨酸残基的修饰产生了对2型TRH受体比对1型具有选择性的类似物。

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Altered ligand dissociation rates in thyrotropin-releasing hormone receptors mutated in glutamine 105 of transmembrane helix III.跨膜螺旋III的谷氨酰胺105位点发生突变的促甲状腺激素释放激素受体中配体解离速率的改变。

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