Maas D H, Hoppe B, Weitzel H K
Fortschr Med. 1979 Jun 7;97(21):981-6.
In 101 patients of the Frauenklinik der Medizinischen Hochschule Hannover we have measured the concentrations of fetal cells and alpha-fetoprotein before and after amniocentesis. There was a significant increase in both parameters corresponding to an arbitrary fetomaternal haemorrhage of 0,05--0,4 ml. AFP seemed to be more reliable than the fetal cell count. The site of placentation was of no influence on the fetomaternal haemorrhage. As less than 0,1 ml rhesus-positive fetal blood is enough to cause isoimmunization in mothers at risk we highly recommend to give immunoglobulin-anti-D to all unsensitized rhesus-negative mothers after amniocentesis.
在汉诺威医学院妇产科的101名患者中，我们测量了羊膜穿刺术前后胎儿细胞和甲胎蛋白的浓度。这两个参数均显著增加，相当于0.05 - 0.4毫升的任意胎儿-母体出血。甲胎蛋白似乎比胎儿细胞计数更可靠。胎盘着床部位对胎儿-母体出血没有影响。由于少于0.1毫升的恒河猴阳性胎儿血液就足以使高危母亲发生同种免疫，我们强烈建议在羊膜穿刺术后给所有未致敏的恒河猴阴性母亲注射抗D免疫球蛋白。
