Novak M
Zavod za neonatologiju i intenzivno lijecenje, Klinika za djecje bolesti Medicinskog fakulteta i KBC Rebro, Zagreb.
Lijec Vjesn. 1995 Jun;117 Suppl 2:16-21.
A significant improvement has been noticed over the last 20 years in children in whom shock syndrome has developed. This has been attained through the application of technological advances in respiratory, cardiovascular, renal, nutritional support and improved antibacterial and antifungal therapy, but mostly through a better understanding of the physiology of shock. Newer concepts of the pathophysiology of sepsis and septic shock are presented, with clinical definitions referring to the pediatric patient. Innovative therapeutic modalities designed to modulate the systemic inflammatory response triggered by bacterial infection are discussed.
在过去20年里，已发现患有休克综合征的儿童情况有了显著改善。这是通过在呼吸、心血管、肾脏、营养支持等方面应用技术进步以及改进抗菌和抗真菌治疗实现的，但主要还是通过对休克生理学有了更好的理解。文中介绍了脓毒症和脓毒性休克病理生理学的更新概念，并给出了针对儿科患者的临床定义。还讨论了旨在调节由细菌感染引发的全身炎症反应的创新治疗方式。
