Bhaskar L, Balasubramanian K A
Wellcome Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore, India.
Life Sci. 1996;58(23):2115-23. doi: 10.1016/0024-3205(96)00205-6.
The colonic lumen is likely to contain oxidants derived from unabsorbed dietary materials including transition metals, rancid fat, drugs and bacterial metabolites. The present study looks at the effect of luminal exposure of different oxidants on colonic mucosal lipid peroxidation and absorptive function. All the oxidants tested induced fluid and electrolyte secretion and indomethacin, a prostaglandin synthesis inhibitor reversed this effect. Oxidants did not induce mucosal lipid peroxidation. This study suggests that oxidants induce functional alterations in colon possibly through stimulation of prostaglandin generation without influencing mucosal lipid peroxidation.
结肠腔可能含有源自未吸收饮食物质的氧化剂，这些物质包括过渡金属、酸败脂肪、药物和细菌代谢产物。本研究观察了不同氧化剂的腔内暴露对结肠黏膜脂质过氧化和吸收功能的影响。所有测试的氧化剂均诱导了液体和电解质分泌，而前列腺素合成抑制剂吲哚美辛可逆转这种效应。氧化剂未诱导黏膜脂质过氧化。本研究表明，氧化剂可能通过刺激前列腺素生成而不影响黏膜脂质过氧化，从而诱导结肠功能改变。
