Saba J D, Obeid L M, Hannun Y A
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):233-40; discussion 240-1. doi: 10.1098/rstb.1996.0021.
Ceramide is an endogenous lipid molecule generated by hydrolysis of membrane sphingomyelin, in response to cellular stimulation by hormones and cytokines. Ceramide appears to have a role in mediating biological responses in a wide variety of cell types. These responses are generally considered anti-proliferative, but endpoints are varied and include differentiation, growth inhibition, senescence and apoptotic cell death. Mechanisms for ceramide action involve regulation of protein phosphorylation via stimulation of a serine/threonine protein phosphatase, a proline-directed kinase and possibly other direct and/or indirect targets.
神经酰胺是一种内源性脂质分子，由膜鞘磷脂水解产生，以响应激素和细胞因子对细胞的刺激。神经酰胺似乎在多种细胞类型中介导生物学反应。这些反应通常被认为具有抗增殖作用，但终点是多样的，包括分化、生长抑制、衰老和凋亡性细胞死亡。神经酰胺作用的机制包括通过刺激丝氨酸/苏氨酸蛋白磷酸酶、脯氨酸定向激酶以及可能的其他直接和/或间接靶点来调节蛋白质磷酸化。
