Uldall P V, Sommer B
Epilepsihospitalet, Dianalund.
Ugeskr Laeger. 1996 Apr 1;158(14):1973-6.
Fifty-two children with intractable epilepsy received lamotrigine as add-on therapy on a compassionate basis. The results were reviewed after three and six months of treatment in order to evaluate the efficacy in different epilepsy syndromes. Mental retardation was present in 60% of the children. Ictal EEG was obtained in 38 children. At three months the median monthly seizure frequency was reduced from 46 to 14 in the 37 children that still received lamotrigine (p < 0.01). Seven children were seizure-free. Seizure reduction was most impressive in generalized epilepsy, since 63% of these had more than 50% seizure reduction compared to 18% in partial epilepsies (p < 0.05). This difference was unchanged after six months of treatment. Side effects were reported in 18 of the children. In 13 children the parents reported an improved wellbeing. Lamotrigine seems to be an efficient antiepileptic drug-especially in generalized epilepsy.
52名患有顽固性癫痫的儿童在同情用药的基础上接受了拉莫三嗪作为附加疗法。在治疗3个月和6个月后对结果进行了回顾，以评估其对不同癫痫综合征的疗效。60%的儿童存在智力迟钝。38名儿童进行了发作期脑电图检查。在仍接受拉莫三嗪治疗的37名儿童中，3个月时每月发作频率中位数从46次降至14次（p<0.01）。7名儿童无癫痫发作。全身性癫痫发作减少最为显著，因为其中63%的患儿癫痫发作减少超过50%，而部分性癫痫患儿中这一比例为18%（p<0.05）。治疗6个月后这一差异没有变化。18名儿童报告有副作用。13名儿童的家长报告其幸福感有所改善。拉莫三嗪似乎是一种有效的抗癫痫药物——尤其是在全身性癫痫中。
