Kita K, Sczurek Z, Kita I
Med Pr. 1977;28(1):7-13.
Rats were administered porridge with pesticide IPO-1250 in doses 50, 200, 800 and 4000 ppm. The animals were killed and subjected to a selective examination. The mass of organs relative to the brain mass was determined and its segments were examined histopathologising. It has been concluded that IPO-1250 affect metabolic processes of rats, a decrease or increase of the inner organs mass. In the examined organs were observed non-specific and generally reversible pathomorphotic changes in the form of circulatory disturbances and regressive changes. The intensity of changes increased typically at the highest applied dose of pesticide = 4000 ppm. The observations allowed to establish the highest dose tolerated by rats which for the preparation IPO-1250 amounts to 800 ppm.
给大鼠喂食含50、200、800和4000 ppm剂量农药IPO - 1250的粥。处死动物并进行选择性检查。测定各器官相对于脑质量的质量，并对其切片进行组织病理学检查。得出的结论是，IPO - 1250影响大鼠的代谢过程，导致内脏器官质量减少或增加。在所检查的器官中观察到以循环障碍和退行性变化形式出现的非特异性且通常可逆的病理形态学改变。在最高施用剂量（4000 ppm）的农药作用下，这些变化的强度通常会增加。这些观察结果确定了大鼠对制剂IPO - 1250的最高耐受剂量为800 ppm。
