慢性丙型肝炎干扰素治疗后出现的结节病。

Sarcoidosis after interferon therapy for chronic active hepatitis C.

作者信息

Teragawa H, Hondo T, Takahashi K, Watanabe H, Ohe H, Hattori N, Watanabe Y, Amano H, Hino F, Ohbayashi M, Urushihara T, Yonehara S

机构信息

Department of Internal Medicine, Onomichi General Hospital.

出版信息

Intern Med. 1996 Jan;35(1):19-23. doi: 10.2169/internalmedicine.35.19.

DOI:10.2169/internalmedicine.35.19

PMID:8652926

Abstract

Sarcoidosis is characterized by multisystemic granulomatous lesions of unknown etiology. A 62-year-old woman developed sarcoidosis after treatment with alpha-2a interferon (IFN) for 24 weeks (total dose: 522 million units) for chronic hepatitis C. She developed complete atrioventricular block and multiple noncaseating granulomatous lesions in the lung. IFN therapy, which may disturb cellular immune activation in some patients, may have contributed to the onset and progression of sarcoidosis.

摘要

结节病的特征是病因不明的多系统肉芽肿性病变。一名62岁女性在接受α-2a干扰素（IFN）治疗慢性丙型肝炎24周（总剂量：5.22亿单位）后发生结节病。她出现了完全性房室传导阻滞，肺部有多个非干酪样肉芽肿性病变。IFN治疗可能会干扰某些患者的细胞免疫激活，可能促使了结节病的发生和进展。