Koshida K, Uchibayashi T, Yamamoto H, Hirano K
Department of Urology, School of Medicine, Kanazawa University, Japan.
Br J Urol. 1996 Jan;77(1):138-42. doi: 10.1046/j.1464-410x.1996.74324.x.
To investigate the significance of placental alkaline phosphatase (PLAP) as a tumour marker for seminoma.
A total of 673 serum samples from 116 patients with testicular germ cell tumours (78 seminomas and 38 non-seminomas) were analysed for several markers including PLAP, total alkaline phosphatase (AL-P), alpha fetoprotein (AFP), beta human chorionic gonadotrophin (HCG-B), and lactic dehydrogenase (LDH).
Serum PLAP was increased initially in about 50% of patients with seminoma, and the mean magnitude of elevation was about five times the normal value. There was no significant correlation between PLAP and LDH or between PLAP and HCG-B. Therefore, a combination of these three markers was of value, and resulted in a positive identification rate of 82% of patients with seminoma. False-positive results for PLAP appeared in 1.6% of 673 samples investigated.
The monitoring of serum PLAP might be of value, as fluctuations in this marker provide information about disease status and prognosis.
探讨胎盘碱性磷酸酶（PLAP）作为精原细胞瘤肿瘤标志物的意义。
对116例睾丸生殖细胞肿瘤患者（78例精原细胞瘤和38例非精原细胞瘤）的673份血清样本进行了多种标志物分析，包括PLAP、总碱性磷酸酶（AL-P）、甲胎蛋白（AFP）、β人绒毛膜促性腺激素（HCG-B）和乳酸脱氢酶（LDH）。
约50%的精原细胞瘤患者血清PLAP最初升高，平均升高幅度约为正常值的5倍。PLAP与LDH之间或PLAP与HCG-B之间无显著相关性。因此，这三种标志物联合使用有价值，精原细胞瘤患者的阳性识别率达82%。在所检测的673份样本中，PLAP出现假阳性结果的比例为1.6%。
监测血清PLAP可能有价值，因为该标志物的波动可提供疾病状态和预后的信息。
