Soosay G N, Parkinson M C, Paradinas J, Fisher C
Department of Histopathology, King George Hospital, Ilford, UK.
Br J Urol. 1996 Jan;77(1):143-6. doi: 10.1046/j.1464-410x.1996.84925.x.
To assess differences in the histopathological diagnoses of a series of paratesticular sarcomas following changes in the morphological classification of these tumours and the availability of investigations to define their immunophenotype, and to consider the impact of these changes on clinical management.
Thirty-six soft tissue tumours of the paratesticular region, originally submitted to the British Testicular Tumour Panel and Registry between 1958 and 1967 were re-examined histologically using modern diagnostic criteria, including immunohistochemical features. Where possible, follow-up was brought up to date.
Thirteen (35%) of the diagnoses made in 1967 were changed; of these, seven changes were attributable to the results of immunohistochemical tests and one involved the identification of an entity not recognized in 1967 (spindle cell rhabdomyosarcoma).
The changes in diagnoses of major clinical relevance involved three neoplasms (8%) in which the recent opinion was rhabdomyosarcoma, a tumour for which successful treatment protocols are currently available.
评估一系列睾丸旁肉瘤在肿瘤形态学分类变化以及用于确定其免疫表型的检查方法出现后，组织病理学诊断上的差异，并探讨这些变化对临床管理的影响。
对1958年至1967年间最初提交给英国睾丸肿瘤小组和登记处的36例睾丸旁区域软组织肿瘤，采用现代诊断标准进行组织学复查，包括免疫组化特征。尽可能更新随访情况。
1967年做出的诊断中有13例（35%）发生了改变；其中，7例改变归因于免疫组化检测结果，1例涉及识别出1967年未被认识的一种实体（梭形细胞横纹肌肉瘤）。
具有主要临床意义的诊断变化涉及三种肿瘤（8%），目前认为这些肿瘤是横纹肌肉瘤，而对于这种肿瘤目前已有成功的治疗方案。
