Wehbe T W, Warth J A
Tufts Medical School, Boston, Massachusetts, USA.
Clin Pharmacol Ther. 1996 Mar;59(3):360-2. doi: 10.1016/S0009-9236(96)80014-2.
Warfarin is one of the most commonly used oral anticoagulants. Many medications have been shown to influence the prothrombin time in patients treated with warfarin by various mechanisms. We observed a major bleeding episode that resulted from a probable interaction between levamisole (Ergamisol), 5-fluorouracil, and warfarin. It is conceivable that many patients who are predisposed to thromboembolism because of cancer and surgery will be taking this combination of medications.
华法林是最常用的口服抗凝剂之一。许多药物已被证明可通过各种机制影响接受华法林治疗患者的凝血酶原时间。我们观察到一起严重出血事件，可能是由左旋咪唑（驱虫净）、5-氟尿嘧啶和华法林之间的相互作用所致。可以想象，许多因癌症和手术而易发血栓栓塞的患者会同时服用这几种药物。
