Grunstein M, Hecht A, Fisher-Adams G, Wan J, Mann R K, Strahl-Bolsinger S, Laroche T, Gasser S
Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90095, USA.
J Cell Sci Suppl. 1995;19:29-36. doi: 10.1242/jcs.1995.supplement_19.4.
Yeast chromosomes may lack the linker histone H1 (normally required to compact 10 nm beads-on-a-string fiber into the 30 nm fiber) and there is no cytological evidence for higher order fiber structure but they do contain regions which correspond to euchromatin and heterochromatin of higher eukaryotes. Both euchromatin and heterochromatin contain nucleosomal particles (composed of two molecules each of H2A, H2B, H3 and H4), however histones have been shown to regulate genes in these regions in quite different ways. The mechanisms by which such regulation occurs are the topic of this paper.
酵母染色体可能缺乏连接组蛋白H1（通常需要它将10纳米的串珠状纤维压缩成30纳米的纤维），并且没有细胞学证据表明存在更高层次的纤维结构，但它们确实包含与高等真核生物常染色质和异染色质相对应的区域。常染色质和异染色质都含有核小体颗粒（由H2A、H2B、H3和H4各两个分子组成），然而，组蛋白已被证明以截然不同的方式调节这些区域的基因。这种调节发生的机制是本文的主题。
