Stampone C, Nicotra M, Muttinelli C, Cosmi E V
University ¿La Sapienza¿, Rome, Italy.
J Clin Ultrasound. 1996 Jan;24(1):3-9. doi: 10.1002/(SICI)1097-0096(199601)24:1<3::AID-JCU1>3.0.CO;2-N.
A cross-sectional study comprising 117 consecutive first trimester singleton pregnancies was performed using transvaginal sonography (TVS) to evaluate size abnormalities of the secondary yolk sac (YS) vis-à-vis pregnancy outcome. In normal pregnancy outcome (NPO) the YS diameter showed an increase from the 5th to the 11th week, menstrual age, followed by a decrease and its disappearance after 12 weeks. A YS of abnormal size was statistically significant (p < 0.001) in spontaneous abortion (SA) versus NPO, with a sensitivity of 68.7%, a specificity of 99%, a positive predictive value of 91.6% and a negative predictive value of 95.2%. These preliminary results indicate that a measurement of the YS very early in gestation may be a useful marker of pregnancy outcome.
一项横断面研究纳入了117例连续的孕早期单胎妊娠，采用经阴道超声（TVS）评估次级卵黄囊（YS）大小异常与妊娠结局的关系。在正常妊娠结局（NPO）中，卵黄囊直径在月经龄第5周至第11周呈增加趋势，随后减小，并在12周后消失。与NPO相比，自发流产（SA）中卵黄囊大小异常具有统计学意义（p < 0.001），敏感性为68.7%，特异性为99%，阳性预测值为91.6%，阴性预测值为95.2%。这些初步结果表明，妊娠早期对卵黄囊的测量可能是妊娠结局的一个有用指标。
