Durán E, Cabezos J, Ros M, Terre M, Zarzuela F, Bada J L
Institut Català de la Salut, Departamento de Genética y Microbiología, Facultad de Medicina, Universidad Autónoma de Barcelona.
Med Clin (Barc). 1996 Apr 13;106(14):525-8.
The aim of the present was to study the prevalence of infection and tuberculous disease as well as the fulfillment of secondary antituberculin chemoprophylaxis in immigrants according to their geographic origin.
A descriptive study was carried out of 1,489 immigrants under the age of 35 years attended in the Tropical and Imported Disease Unit Drassanes in Barcelona, Spain from 1989 to 1994.
The patients were from 79 countries, with 81.7% being males and 18.3% females (p < 0.001) of a mean age 26.1 +/- 5.7 and 23.4 +/- 7.5 years, respectively. Forty-three percent of the cases presented Mantoux test response > or = 10 mm of induration. The highest percent of positivity was observed in patients from Subsaharian Africa (52%) followed by Eastern Europeans and Asians (44%), South and Central Americans (38%) and Middle East and Northern Africa (34%) (p < 0.001). Thirty-nine percent of the 359 patients who initiated secondary antituberculin chemoprophylaxis completed the 6 months of treatment with the highest fulfillment being found in Africans (49%) followed by Americans (42%) and Asians (39%). The lowest rate was observed in the Eastern Europeans (20%) (p < 0.001). Fifty-six percent of the patients abandoned secondary antituberculin prophylaxis within the first three months. Eighteen cases of active tuberculosis were diagnosed.
The prevalence of tuberculous infection and disease is high immigrants in Barcelona, Spain. The fulfillment of chemoprophylaxis is low and abandoned early. These facts should be evaluated when designing prevention and control programs.
本研究旨在根据移民的地理来源，研究感染和结核病的患病率以及继发性抗结核化学预防的实施情况。
对1989年至1994年在西班牙巴塞罗那德拉桑内斯热带与输入性疾病科就诊的1489名35岁以下移民进行了描述性研究。
患者来自79个国家，男性占81.7%，女性占18.3%（p<0.001），平均年龄分别为26.1±5.7岁和23.4±7.5岁。43%的病例结核菌素试验硬结反应≥10mm。撒哈拉以南非洲患者的阳性率最高（52%），其次是东欧和亚洲患者（44%）、南美洲和中美洲患者（38%）以及中东和北非患者（34%）（p<0.001）。在开始进行继发性抗结核化学预防的359名患者中，39%完成了6个月的治疗，完成率最高的是非洲人（49%），其次是美国人（42%）和亚洲人（39%）。东欧人的完成率最低（20%）（p<0.001）。56%的患者在头三个月内放弃了继发性抗结核预防。诊断出18例活动性结核病。
在西班牙巴塞罗那，移民中结核感染和疾病的患病率很高。化学预防的完成率低且早期就被放弃。在设计预防和控制方案时应评估这些情况。
