Precocious puberty with pituitary gland hyperplasia: two cases in one family.

Children with central precocious puberty have pituitary gland size comparable to that of pubertal children (pituitary gland height 6.1 +/- 1.1 mm). We present of two sisters with precocious puberty and a pituitary gland height of more than 1 cm. On contrast enhanced MRI, there was homogeneous enhancement of the pituitary gland. There was no increase in pituitary gland size during the follow-up period (6 years and 2 years). These cases are reported for their rarity.