Kuśnierczyk P
Laboratorium Immunogenetyki Zakładu Immunologii Klinicznej.
Postepy Hig Med Dosw. 1995;49(1):33-45.
Human major histocompatibility complex class I molecules, HLA-A and -B, bind peptides derived from intracellular proteins, transport them to the cell surface and present them to T lymphocytes. Much less is known about the function of the third "classical" class I molecule, HLA-C. Recent data disclosing remarkable polymorphism of HLA-C, possible importance of this molecule for the recognition of target cells by nature killer cells, and capability to present viral antigens to the T lymphocytes are reviewed. Preliminary results from our laboratory on binding of synthesis peptides to HLA-Cw3+ cells are presented.
人类主要组织相容性复合体I类分子，即HLA - A和 - B，结合源自细胞内蛋白质的肽段，将它们转运至细胞表面并呈递给T淋巴细胞。对于第三个“经典”I类分子HLA - C的功能，人们了解得要少得多。本文综述了近期的数据，这些数据揭示了HLA - C显著的多态性、该分子对于自然杀伤细胞识别靶细胞可能具有的重要性以及向T淋巴细胞呈递病毒抗原的能力。文中还展示了我们实验室关于合成肽与HLA - Cw3 + 细胞结合的初步结果。
