Anzai Y, Carroll W R, Quint D J, Bradford C R, Minoshima S, Wolf G T, Wahl R L
Department of Radiology, University of Michigan Medical Center, University Hospital, Ann Arbor 48109-0028, USA.
Radiology. 1996 Jul;200(1):135-41. doi: 10.1148/radiology.200.1.8657901.
To evaluate the diagnostic accuracy of positron emission tomography (PET) with administration of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) relative to that of magnetic resonance (MR) imaging and/or computed tomography (CT) in recurrent head and neck cancers.
Twelve adult patients (mean age, 63 years) with previously treated head and neck cancers and clinical suspicion of recurrence underwent FDG PET and MR imaging and/or CT. All images were blindly and independently interpreted without histopathologic findings (obtained within 1 week of imaging). The level of confidence in image interpretation was graded by using a five-point rating system (0 = definitely no recurrence to 4 = definite recurrence).
Recurrence was confirmed in eight patients. With a rating of 4 as a positive finding, FDG PET yielded a sensitivity and specificity of 88% (seven of eight) and 100% (four of four), respectively; MR imaging and/or CT, 25% (two of eight) and 75% (three of four), respectively. Receiver-operating characteristic analysis showed significantly better diagnostic accuracy with FDG PET than with MR imaging and/or CT (area under curve = 0.96 vs 0.55, P < .03).
These data indicate that PET metabolic imaging, as compared with anatomic methods, has improved diagnostic accuracy for recurrent head and neck cancer.
评估相对于磁共振成像（MR）和/或计算机断层扫描（CT），给予2-脱氧-2-[氟-18]氟-D-葡萄糖（FDG）的正电子发射断层扫描（PET）在复发性头颈癌中的诊断准确性。
12例曾接受过头颈癌治疗且临床怀疑复发的成年患者（平均年龄63岁）接受了FDG PET及MR成像和/或CT检查。所有图像均在无组织病理学结果（在成像后1周内获得）的情况下由专人独立进行盲法解读。图像解读的置信度采用五点评分系统进行分级（0 = 肯定无复发至4 = 肯定复发）。
8例患者确诊复发。以评分为4作为阳性发现，FDG PET的敏感性和特异性分别为88%（8例中的7例）和100%（4例中的4例）；MR成像和/或CT的敏感性和特异性分别为25%（8例中的2例）和75%（4例中的3例）。受试者操作特征分析显示，FDG PET的诊断准确性显著优于MR成像和/或CT（曲线下面积 = 0.96对0.55，P <.03）。
这些数据表明，与解剖学方法相比，PET代谢成像对复发性头颈癌具有更高的诊断准确性。
