头颈癌：利用正电子发射断层显像（PET）和2-[F-18]氟-2-脱氧-D-葡萄糖检测复发情况
Head and neck cancer: detection of recurrence with PET and 2-[F-18]fluoro-2-deoxy-D-glucose.
作者信息
Lapela M, Grénman R, Kurki T, Joensuu H, Leskinen S, Lindholm P, Haaparanta M, Ruotsalainen U, Minn H
机构信息
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.
出版信息
Radiology. 1995 Oct;197(1):205-11. doi: 10.1148/radiology.197.1.7568825.
PURPOSE
To evaluate positron emission tomography (PET) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in detection of suspected recurrence of head and neck cancer, and to compare visual, static, and kinetic analyses of the tracer uptake.
MATERIALS AND METHODS
Seventeen dynamic FDG PET studies were performed in 15 patients. The images were interpreted visually, and the uptake was quantitated as the standardized uptake value (SUV) and as the regional FDG metabolic rate.
RESULTS
Sensitivity of blinded visual interpretation of the PET images for the presence of malignancy was 88% and specificity was 86%. Malignant lesions accumulated significantly more FDG than benign lesions (P = .008 for SUVs, P = .002 for regional metabolic rates). When maximum uptake of FDG in the benign lesions was used as a threshold, the sensitivity of SUV analysis for malignancy was 75% and that of regional metabolic rates was 86%.
CONCLUSION
Detection of recurrent head and neck cancer is feasible with FDG PET. Quantitation of FDG uptake assists in correct interpretation of the PET images.
目的
评估采用2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）的正电子发射断层扫描（PET）在检测头颈部癌疑似复发中的应用，并比较示踪剂摄取的视觉、静态和动态分析。
材料与方法
对15例患者进行了17次动态FDG PET研究。对图像进行视觉解读，并将摄取量定量为标准化摄取值（SUV）和区域FDG代谢率。
结果
PET图像对恶性肿瘤存在的盲法视觉解读的敏感性为88%，特异性为86%。恶性病变比良性病变摄取的FDG明显更多（SUV的P = 0.008，区域代谢率的P = 0.002）。当将良性病变中FDG的最大摄取量用作阈值时，SUV分析对恶性肿瘤的敏感性为75%，区域代谢率分析的敏感性为86%。
结论
FDG PET检测头颈部癌复发是可行的。FDG摄取的定量有助于正确解读PET图像。
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