Tzardis P J, Vougiouklakis D, Lymperi M, Kritikos E, Paraschou E, Tierris E, Stavridis J
1st Surgical Department, Red Cross Hospital, Athens, Greece.
Surg Endosc. 1996 May;10(5):533-6. doi: 10.1007/BF00188402.
The aim of this experimental study is to assess the consequences of biliary stones placed in the abdominal cavity of rabbits.
The animals were allocated to five groups. In group A a nonsterile gallstone was used. In group B animals with a nonsterile gallstone received preoperative chemoprophylaxis. In group C a sterile stone was placed in the abdomen. Group D served as control. In group E were animals with a nonsterile stone who had a prolonged follow-up period. Parameters studied postoperatively were temperature, white blood cell count, abscess formation, sepsis, peritonitis, adhesion formation, intestinal obstruction, and histological changes of the omentum enveloping the gallstones.
There was no statistically significant difference among the five groups concerning morbidity, mortality, or histological findings.
The prevalence of septic complications was higher among the four groups that received gallstones compared to the control group and thus an adverse effect of gallstone implantation can be suggested.
本实验研究旨在评估将胆结石置于兔腹腔内的后果。
将动物分为五组。A组使用非无菌胆结石。B组使用非无菌胆结石的动物接受术前化学预防。C组将无菌结石置于腹腔内。D组作为对照组。E组是使用非无菌结石且随访期延长的动物。术后研究的参数包括体温、白细胞计数、脓肿形成、败血症、腹膜炎、粘连形成、肠梗阻以及包裹胆结石的大网膜的组织学变化。
五组在发病率、死亡率或组织学结果方面无统计学显著差异。
与对照组相比，接受胆结石的四组中感染性并发症的发生率更高，因此可以认为胆结石植入有不良影响。
