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[软性隐形眼镜药物解吸规律。2. 体外研究]

[Regularities of drug desorption from soft contact lenses. 2. In vitro study].

作者信息

Rybakova E G, Avetisov S E, Badun G A, Krasnianskiĭ A V

出版信息

Vestn Oftalmol. 1996 Jan-Mar;112(1):18-20.

PMID:8659062
Abstract

Radiometry of distribution of drugs introduced with soft contact lenses (with 40 and 70% humor content and thickness of 0.2 and 0.7 mm) in the ocular cavity was carried out to compare this mode of drug administration with the traditional methods. The maximal concentrations of the drugs in the anterior chamber humor and in the vitreous body were attained by using saturated highly hydrophilic 0.7 mm thick contact lenses. The drug content in the anterior chamber of the eye upon such a mode of administration was higher than after injection and much higher than after instillation.

摘要

对采用软性隐形眼镜(含水量分别为40%和70%,厚度分别为0.2毫米和0.7毫米)引入眼腔的药物分布进行了辐射测量,以将这种给药方式与传统方法进行比较。通过使用饱和的、高度亲水的0.7毫米厚隐形眼镜,在前房房水和玻璃体中达到了药物的最大浓度。以这种给药方式时,眼内前房中的药物含量高于注射后,且远高于滴注后。

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