Krasnov M M, Ziangirova G G, Antonova O V
Vestn Oftalmol. 1996 Jan-Mar;112(1):24-6.
Morphologic analysis of 173 biopsy specimens of the iris and sclera removed during antiglaucoma surgery in 115 patients with open-angle glaucoma revealed in 44.4% cases extracellular depositions of amyloid, which aggravated the course of glaucomatous process and were pathogenetically significant. Amyloidosis was revealed in the sclera in 82% cases and in the iris in 70%. Amyloid was detected by Congo red staining with control in polarized light and by toluidine blue staining for chondroitin and dermatan sulfates. Vascular and muscular (involving the pupil muscles) forms of amyloidosis were detected in the iris, pericollagen and focal forms in the draining system and sclera. The authors discuss the contribution of amyloidosis to the pathogenesis of glaucoma. These findings confirm M.M. Krasnov's concept about glaucoma polymorphism.
对115例开角型青光眼患者抗青光眼手术中摘除的173份虹膜和巩膜活检标本进行形态学分析，结果显示44.4%的病例存在淀粉样蛋白细胞外沉积，这加剧了青光眼病程，且在发病机制上具有重要意义。82%的病例在巩膜中发现淀粉样变性，70%在虹膜中发现。通过刚果红染色并在偏振光下对照以及甲苯胺蓝染色检测硫酸软骨素和硫酸皮肤素，检测到淀粉样蛋白。在虹膜中检测到血管性和肌肉性（涉及瞳孔肌肉）淀粉样变性形式，在引流系统和巩膜中检测到胶原周和局灶性形式。作者讨论了淀粉样变性在青光眼发病机制中的作用。这些发现证实了M.M. 克拉斯诺夫关于青光眼多态性的概念。
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