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[虹膜和巩膜淀粉样变性在青光眼发病机制中的作用]

[Amyloidosis of the iris and sclera in the pathogenesis of glaucoma].

作者信息

Ziangirova G G, Antonova O V

出版信息

Izv Akad Nauk Ser Biol. 1995 Sep-Oct(5):586-9.

PMID:8520437
Abstract

Morphological analysis of 173 biopsies of the iris and sclera removed during antiglaucoma operations in 115 patients with open angle glaucoma showed extracellular deposits of amyloid in 44.4% of cases, which complicated the course of glaucomatous process and had pathogenetic importance. Amyloid was identified by Congo red [correction of Congo-rot] staining with the control in the polarized light and also by toluidine blue staining for chondroitin and dermatan sulfates. The vascular and muscle (pupillary muscle) forms of amyloidosis were found in the iris and the pericollagen and focal forms in the drainage system and sclera. We propose to classify the amyloid form of glaucoma with specific morphological picture.

摘要

对115例开角型青光眼患者抗青光眼手术中摘除的173份虹膜和巩膜活检标本进行形态学分析,结果显示44.4%的病例存在细胞外淀粉样沉积物,这使青光眼病程复杂化并具有致病重要性。淀粉样物质通过刚果红染色在偏振光下对照鉴定,也通过甲苯胺蓝染色检测硫酸软骨素和硫酸皮肤素进行鉴定。在虹膜中发现了血管性和肌肉性(瞳孔肌)淀粉样变性形式,在引流系统和巩膜中发现了胶原周和局灶性形式。我们建议对具有特定形态学表现的青光眼淀粉样变性形式进行分类。

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