Fernández Arjona M, Romero Tejada J C, Teba del Pino F, Peinado F, Rabadán M, Herrero L, Pereira I
Servicio de Urología, Hospital de La Princesa, Facultad de Medicina de la Universidad Autonoma, Madrid.
Actas Urol Esp. 1995 Mar;19(3):187-91.
A prospective study was designed to get to know the reliability of PSA density and PSA age index as tools in the diagnostic approach for prostate carcinoma. It was noted that PSA age index is more susceptible than PSA density to diagnose prostate cancer. We noted also that up to 80% of patients with prostate cancer and intermediate PSA levels have PSA density < 0.15 and that, according to current protocols biopsy should not have been performed. It was concluded that the value of PSA age index is at least equal to PSA density, but it eradicates the subjectivity introduced by this data because of the need of measuring prostate volume. We believe that in the future it may be indicated to perform biopsies at PSA levels above 4 ng/ml, and it may be necessary to decrease PSa normal density levels down to 0.1 or less.
一项前瞻性研究旨在了解前列腺特异性抗原（PSA）密度和PSA年龄指数作为前列腺癌诊断方法工具的可靠性。结果表明，PSA年龄指数比PSA密度更易诊断前列腺癌。我们还注意到，高达80%的前列腺癌患者且PSA水平处于中等范围者，其PSA密度<0.15，按照当前方案本不应进行活检。结论是，PSA年龄指数的价值至少与PSA密度相当，但它消除了因测量前列腺体积而给该数据带来的主观性。我们认为，未来可能建议在PSA水平高于4 ng/ml时进行活检，且可能有必要将PSA正常密度水平降至0.1或更低。
