Wang A Y, Lai K N, Lai F M, Leung C B, Li P K
Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, New Territories, Hong Kong.
Am J Kidney Dis. 1996 Feb;27(2):267-9. doi: 10.1016/s0272-6386(96)90551-x.
Identical twins presented at the same time with renal failure. They also recalled a simultaneous history of "nephritis" as early as the age of 6 years. Renal biopsies revealed variably thickened glomerular basement membranes with the lamellation and splitting characteristic of Alport's syndrome. Bilateral sensorineural deafness was demonstrated in both twins on audiometric testing. A positive family history in the mother and one elder sister confirmed the diagnosis of Alport's syndrome. This is the first reported case of Alport's syndrome occurring in monozygotic twins.
同卵双胞胎同时出现肾衰竭。他们还回忆起早在6岁时就有过同时患“肾炎”的病史。肾活检显示肾小球基底膜不同程度增厚，具有阿尔波特综合征的分层和分裂特征。听力测试表明，这对双胞胎均患有双侧感音神经性耳聋。母亲和一位姐姐的阳性家族史证实了阿尔波特综合征的诊断。这是首例报道的同卵双胞胎患阿尔波特综合征的病例。
