Buelow J M, Aydelott P, Pierz D M, Heck B
Rush Epilepsy Center, Rush-Presbyterian-St Luke's Medical Center, Chicago, USA.
AORN J. 1996 Apr;63(4):727-9, 732-5, 737-9; quiz 741-4. doi: 10.1016/s0001-2092(06)63123-2.
Landau-Kleffner syndrome (LKS) is an acquired epileptic aphasia caused by a lesion in the speech centers of the cerebral cortex during a critical period of childhood development. Characteristics of LKS include language deterioration, seizure disorders, and severe electroencephalogram abnormalities. Multiple subpial transection (MST) is a surgical procedure that eliminates seizure activity in the cerebral cortex while preserving the child's normal cortical functions of speech, movement, primary sensation, and memory. This article presents a summary of clinical studies on LKS and discusses the diagnosis of LKS, traditional medical treatments, patient selection for MST procedures, and perioperative care of children undergoing MST procedures.
Landau-Kleffner综合征（LKS）是一种在儿童发育关键期由大脑皮质语言中枢病变引起的获得性癫痫性失语症。LKS的特征包括语言退化、癫痫发作障碍和严重的脑电图异常。多处软膜下横切术（MST）是一种手术程序，可消除大脑皮质的癫痫活动，同时保留儿童正常的语言、运动、主要感觉和记忆皮质功能。本文概述了关于LKS的临床研究，并讨论了LKS的诊断、传统医学治疗、MST手术的患者选择以及接受MST手术儿童的围手术期护理。
