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A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.

作者信息

Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle D A, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy R L, Shows T B, Collins F S, Shiloh Y, Rotman G

机构信息

Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.

出版信息

Genomics. 1996 Apr 15;33(2):199-206. doi: 10.1006/geno.1996.0184.

DOI:10.1006/geno.1996.0184
PMID:8660968
Abstract

A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.

摘要

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