HIV-1 衣壳蛋白与微丝中存在的 F-肌动蛋白相关联。

HIV-1 Gag protein associates with F-actin present in microfilaments.

作者信息

Rey O, Canon J, Krogstad P

机构信息

Department of Pediatrics, School of Medicine, University of California at Los Angeles 90095, USA. <

出版信息

Virology. 1996 Jun 15;220(2):530-4. doi: 10.1006/viro.1996.0343.

DOI:10.1006/viro.1996.0343

PMID:8661406

Abstract

Several studies have provided evidence that the cellular cytoskeleton may be involved in the assembly and budding of retroviruses. In fractionation studies of HIV-1-infected CEM cells, the majority of the unprocessed Gag polyprotein cofractionated with the cellular cytoskeleton. In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1.

摘要

多项研究已提供证据表明，细胞细胞骨架可能参与逆转录病毒的组装和出芽过程。在对感染HIV-1的CEM细胞进行的分级分离研究中，大多数未加工的Gag多聚蛋白与细胞细胞骨架共同分级分离。对这种相互作用的体内和体外分析表明，未加工的Gag多聚蛋白能够与聚合肌动蛋白（F-肌动蛋白）结合。Gag与F-肌动蛋白的结合可能参与HIV-1的组装或出芽。