Vincent J L
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B-1070 Brussels, Belguim.
World J Surg. 1996 May;20(4):465-70. doi: 10.1007/s002689900073.
Multiple organ failure (MOF) stems from a complex interaction between the host's immune response and inadequate tissue perfusion. Prevention of MOF therefore addresses these two components. The risk of inflammation is reduced through treatment of any infection and early stabilization of traumatized regions. Adequate respiratory and cardiocirculatory resuscitation is achieved to restore and maintain tissue perfusion. Although a supranormal cardiac output is often indicated, it is difficult to define precise endpoints for hemodynamic stabilization. Instead of increasing the oxygen supply to supranormal values in all patients, it is probably safer and more effective to increase it only in those patients for whom persistent ischemia is suspected. Provision of adequate nutritional support is important, and whenever possible the enteral route is preferred. Once MOF has developed, treatment turns to support of individual organs. Unfortunately, there is no single treatment for MOF that seems to reverse the associated trend of high mortality. Survival is more likely when the cause of MOF can be found and eliminated.
多器官功能衰竭（MOF）源于宿主免疫反应与组织灌注不足之间的复杂相互作用。因此，MOF的预防涉及这两个方面。通过治疗任何感染以及早期稳定创伤区域来降低炎症风险。实现充分的呼吸和心血管复苏以恢复和维持组织灌注。尽管通常需要超常的心输出量，但很难确定血流动力学稳定的精确终点。与其在所有患者中将氧气供应增加到超常水平，可能仅在怀疑存在持续性缺血的患者中增加氧气供应更安全、更有效。提供充足的营养支持很重要，并且只要有可能，首选肠内途径。一旦发生MOF，治疗就转向对各个器官的支持。不幸的是，没有一种单一的MOF治疗方法似乎能扭转相关的高死亡率趋势。当能够找到并消除MOF的病因时，存活的可能性更大。
