Dratman M B, Crutchfield F L, Axelrod J, Utiger R D, Marsh E
Pharmacology. 1977;15(3):193-207. doi: 10.1159/000136690.
To determine whether changes in adrenergic nerve terminal activity may influence tissue metabolism of iodothyronines, sympathetic nervous function of the rat submaxillary salivary gland was altered, and effects on salivary gland triiodothyronine (T3) uptake and retention measured. Following unilateral superior cervical ganglionectomy, denervated salivary gland contained 24% less (p less than 0.02) radioimmunoassayable T3/mg and took up 20% less (p less than 0.001) intravenously administered 125I-T3/mg than the contralateral innervated gland. Effects were similar at 7, 14 and 56 days following ganglionectomy and could not be accounted for by post-denervation changes in the delivery of the isotope, in total salivary gland water, in vascular volume or in extracellular or intracellular fluid spaces. When reserpine was administered to unilaterally ganglionectomized animals, uptake of 125I-T3/mg in the innvervated gland was reduced by 10% (p less than 0.005), relative to the denervated gland. The results suggest that loss or diminution of peripheral adrenergic nerve terminal activity reduces tissue uptake and retention of T3.
为了确定肾上腺素能神经末梢活动的变化是否会影响甲状腺素的组织代谢，对大鼠颌下唾液腺的交感神经功能进行了改变，并测量了其对唾液腺三碘甲状腺原氨酸（T3）摄取和潴留的影响。单侧颈上神经节切除术后，去神经支配的唾液腺每毫克放射性免疫可测T3含量比另一侧有神经支配的腺体少24%（p<0.02），静脉注射的125I-T3每毫克摄取量少20%（p<0.001）。神经节切除术后7天、14天和56天的效应相似，且不能用去神经支配后同位素输送、唾液腺总含水量、血管容量或细胞外或细胞内液间隙的变化来解释。当给单侧神经节切除的动物注射利血平时，有神经支配的腺体中125I-T3每毫克的摄取量相对于去神经支配的腺体减少了10%（p<0.005）。结果表明，外周肾上腺素能神经末梢活动的丧失或减弱会降低T3的组织摄取和潴留。
