Hidalgo L, Villanueva A, Soler T, Matías Guiu X, Capellá G
Servicio de Cirugía General, Consorci Sanitari de Mataró.
Rev Esp Enferm Dig. 1996 Feb;88(2):137-40.
The presence of molecular alterations in the c-K-ras and p53 genes in a small bowel adenocarcinoma arising in a case of Peutz-Jeghers syndrome is reported. The absence of mutations at codon 12 and 13 of the c-K-ras gene in the hamartoma and carcinoma indicates that this oncogene does not contribute to its development. On the other hand, p53 protein overexpression was detected in a small proportion (5-10%) of adenocarcinoma cells. Our findings suggest that p53 inactivation occur in late stages of tumour progression.
报告了一例黑斑息肉综合征患者发生的小肠腺癌中c-K-ras和p53基因的分子改变情况。错构瘤和癌组织中c-K-ras基因第12和13密码子无突变，表明该癌基因对其发生发展无作用。另一方面，在一小部分（5-10%）腺癌细胞中检测到p53蛋白过表达。我们的研究结果提示p53失活发生在肿瘤进展的晚期。
