Nuyts R M, Boot N, van Best J A, Edelhauser H F, Breebaart A C
Department of Ophthalmology, University of Maastricht, Netherlands.
Br J Ophthalmol. 1996 Jan;80(1):15-20. doi: 10.1136/bjo.80.1.15.
To investigate the long term relation between corneal thickness, endothelial morphometric variables, and endothelial permeability in patients with endothelial cell counts under 900 cells/mm2 as a result of endothelial cell destruction after cataract surgery.
Eighteen patients developed the so called toxic endothelial cell destruction (TECD) syndrome following routine cataract surgery because of the intracameral injection of a toxic detergent residue. Ten patients with a mean (SEM) initial cell loss of 72% (2%) were followed for 4 years. Data were obtained at 6 months and 4 years postoperatively and compared between TECD eyes and contralateral control eyes.
Mean (SEM) endothelial cell density of the TECD eyes increased from 642 (41) cells/mm2 to 849 (50) cells/mm2 at 4 years postoperatively (p = 0.005). There was no difference in coefficient of variation or percentage hexagonals between 6 months and 4 years postoperatively. Mean (SD) corneal thickness of the TECD eyes and control eyes was similar, 0.51 (0.02) mm and 0.49 (0.01) mm, respectively (p = 0.65). Mean (SD) endothelial permeability was also similar for TECD eyes and control eyes (4.3 (0.9) x 10(-4) cm/min and 4.4 (0.6) x 10(-4) cm/min, respectively (p = 0.57). There was no correlation between endothelial cell density, coefficient of variation, or percentage of hexagonal cells and endothelial permeability in the TECD eyes. In three patients a permanent corneal decompensation occurred.
Four years after TECD corneal endothelial wound healing is stable and the barrier function has been restored.
研究白内障手术后因内皮细胞破坏导致内皮细胞计数低于900个细胞/mm²的患者角膜厚度、内皮形态计量学变量与内皮通透性之间的长期关系。
18例患者在常规白内障手术后因前房内注入有毒洗涤剂残留而出现所谓的毒性内皮细胞破坏（TECD）综合征。对10例平均（标准误）初始细胞损失72%（2%）的患者进行了4年的随访。在术后6个月和4年获取数据，并在TECD眼和对侧对照眼之间进行比较。
TECD眼的平均（标准误）内皮细胞密度在术后4年从642（41）个细胞/mm²增加到849（50）个细胞/mm²（p = 0.005）。术后6个月和4年之间，变异系数或六边形细胞百分比没有差异。TECD眼和对照眼的平均（标准差）角膜厚度相似，分别为0.51（0.02）mm和0.49（0.01）mm（p = 0.65）。TECD眼和对照眼的平均（标准差）内皮通透性也相似（分别为4.3（0.9）×10⁻⁴cm/min和4.4（0.6）×10⁻⁴cm/min，p = 0.57）。TECD眼中内皮细胞密度、变异系数或六边形细胞百分比与内皮通透性之间无相关性。3例患者发生了永久性角膜失代偿。
TECD后4年，角膜内皮伤口愈合稳定，屏障功能已恢复。
