Manoach M, Varon D, Erez M
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv, Israel.
J Basic Clin Physiol Pharmacol. 1993 Oct-Dec;4(4):273-80. doi: 10.1515/jbcpp.1993.4.4.273.
Ventricular fibrillation (VF) is the most life-threatening arrhythmia. It has been suggested that VF in humans is always sustained. Recent publications indicated that VF can be either sustained (SVF) or transient (TVF), reverting spontaneously into sinus rhythm. In previous studies we have hypothesized that TVF requires, during VF, a high cardiac catecholamine level ([CA]). Since during VF sympathetic activity is enhanced, the question arises of why VF is sustained in the majority of cases. Looking on the living body as a self-protecting servo-mechanism, we propose a servo-model that on the one hand describes the mechanism involved in TVF and on the other proposes a therapeutic procedure which can help the heart in its effort to transform VF into TVF. Our model has been examined by various experimental studies. The results obtained strongly support our hypothesis.
心室颤动（VF）是最危及生命的心律失常。有人提出人类的心室颤动总是持续性的。最近的出版物表明，心室颤动可以是持续性的（SVF）或短暂性的（TVF），可自发恢复为窦性心律。在先前的研究中，我们假设短暂性心室颤动在心室颤动期间需要较高的心脏儿茶酚胺水平（[CA]）。由于在心室颤动期间交感神经活动增强，因此出现了为什么在大多数情况下心室颤动是持续性的问题。将活体视为一种自我保护的伺服机制，我们提出了一种伺服模型，该模型一方面描述了短暂性心室颤动所涉及的机制，另一方面提出了一种治疗程序，该程序可以帮助心脏努力将心室颤动转变为短暂性心室颤动。我们的模型已通过各种实验研究进行了检验。所获得的结果有力地支持了我们的假设。
