Torres E, Calmet F, Barrós P
Universidad Peruana Cayetano Heredia.
Rev Gastroenterol Peru. 1996 Jan-Apr;16(1):20-6.
A prospective study in thirty one patients with ascites, who were hospitalized at Cayetano Heredia National Hospital (H.N.C.H.), to investigate the association between the high serum-to-ascites albumin concentration gradient (high GRAD-Alb) with the degree and development of oesophageal varices, studied by endoscopy, is here reported. It was also studied its relationship with the degree of impairment of liver function, determined by the Child-Pugh's score. In addition our series found that the degree of high GRAD-Alb could discriminate patients with oesophageal varices finding like a signal of its presence a value of high GRAD-Alb greater than 1.435 +/- 0.015 g/dl. It is here demonstrated that the degree of high GRAD-Alb does not have any relationship with the degree of impairment of liver function (Child-Pugh's score), prothrombine time, serum bilirrubin, degree of encephalopathy neither grade of ascites; however, we found a light association and correlation with serum albumin.
一项针对31例腹水患者的前瞻性研究报告如下，这些患者均在卡耶塔诺·埃雷迪亚国家医院（H.N.C.H.）住院，研究血清-腹水白蛋白浓度梯度（高GRAD-Alb）与经内镜检查的食管静脉曲张程度及发展之间的关联。同时还研究了其与由Child-Pugh评分确定的肝功能损害程度之间的关系。此外，我们的系列研究发现，高GRAD-Alb程度可区分食管静脉曲张患者，发现高GRAD-Alb值大于1.435±0.015 g/dl可作为其存在的一个信号。研究表明，高GRAD-Alb程度与肝功能损害程度（Child-Pugh评分）、凝血酶原时间、血清胆红素、肝性脑病程度及腹水分级均无关联；然而，我们发现其与血清白蛋白存在轻度关联及相关性。
