Jindal R M, Sidner R A, Hughes D, Pescovitz M D, Leapman S B, Milgrom M L, Lumeng L, Filo R S
Division of Transplantation, Indiana University School of Medicine, Indianpolis 46202, USA.
Clin Transplant. 1996 Apr;10(2):213-7.
We analyzed the metabolic problems in recipients of liver transplants. Immunosuppression consisted of cyclosporine, steroids and azathioprine. With a mean follow up of 3.5 yr, 37% of 71 recipients were rendered permanently diabetic and hyperlipidemic. Recipients who developed posttransplant diabetes had higher cholesterol levels and proteinuria, but decreased creatinine clearance. Transplant recipients who developed posttransplant hyperlipidemia had greater proteinuria, but their sugars and creatinine clearance were comparable to those who did not have hyperlipidemia. The most significant factor responsible for these metabolic complications was the total dosage of prednisone and cyclosporine. There was no effect of risk antigens on the development of diabetes.
我们分析了肝移植受者的代谢问题。免疫抑制方案包括环孢素、类固醇和硫唑嘌呤。平均随访3.5年，71名受者中有37%出现永久性糖尿病和高脂血症。发生移植后糖尿病的受者胆固醇水平和蛋白尿较高，但肌酐清除率降低。发生移植后高脂血症的移植受者蛋白尿较多，但其血糖和肌酐清除率与未发生高脂血症的受者相当。导致这些代谢并发症的最主要因素是泼尼松和环孢素的总剂量。风险抗原对糖尿病的发生没有影响。
