Simon T C, Gordon J I
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Curr Opin Genet Dev. 1995 Oct;5(5):577-86. doi: 10.1016/0959-437x(95)80026-3.
Decisions commonly made during development that affect proliferation, cell fate specification, differentiation, migration, and death are made repeatedly in the mouse small intestinal epithelium throughout adulthood. The results of these decisions are a stratification of proliferation, differentiation, and death along the mouse small intestine's crypt/villus axis. Recent genetic studies in Caenorhabditis elegans and Drosophila melanogaster have identified factors involved in determining cell fate and differentiation in gut endoderm. The stem cell hierarchy of the adult mouse intestinal epithelium makes it ideally suited for using chimeric animals to examine the functions of homologs of these lower eukaryotic (and other) proteins.
在发育过程中通常做出的影响增殖、细胞命运特化、分化、迁移和死亡的决定，在成年小鼠小肠上皮中会在整个成年期反复做出。这些决定的结果是沿着小鼠小肠的隐窝/绒毛轴出现增殖、分化和死亡的分层。最近在秀丽隐杆线虫和黑腹果蝇中的遗传学研究已经确定了参与决定肠道内胚层细胞命运和分化的因素。成年小鼠肠道上皮的干细胞层级结构使其非常适合用于利用嵌合体动物来研究这些低等真核生物（及其他）蛋白质同源物的功能。
