BSAP（Pax-5）在B细胞发育中的作用。
The role of BSAP (Pax-5) in B-cell development.
作者信息
Busslinger M, Urbánek P
机构信息
Research Institute of Molecular Pathology, Vienna, Austria.
出版信息
Curr Opin Genet Dev. 1995 Oct;5(5):595-601. doi: 10.1016/0959-437x(95)80028-x.
The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
最近，通过对小鼠进行靶向基因失活，分析了B细胞发育过程中转录控制的层次结构。通过这种方式，已证明编码B细胞特异性转录因子BSAP的含配对盒基因Pax-5在早期B淋巴细胞生成中起关键作用。其他实验策略表明，BSAP在B细胞分化后期的细胞增殖、同种型转换和免疫球蛋白重链基因的转录控制中发挥作用。
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