Hill S, Thomas J M
Department of Surgery, Chelsea and Westminster Hospital and Royal Marsden Hospital, London, UK.
Br J Surg. 1996 Apr;83(4):509-12. doi: 10.1002/bjs.1800830425.
Between October 1988 and November 1994, 100 patients with cutaneous metastases from malignant melanoma were treated by carbon dioxide laser ablation under local or general anaesthesia as appropriate. There were minimal postoperative complications and most wounds healed within 6 weeks. A total of 34 of the 53 patients in this series with stage IIIa disease were controlled with four or fewer laser ablations during the first year from presentation. This technique provides a simple effective alternative to hyperthermic isolated limb perfusion with melphalan. Patients with disease not controlled by laser can be considered for isolated limb perfusion.
1988年10月至1994年11月期间，100例恶性黑色素瘤皮肤转移患者根据情况在局部或全身麻醉下接受了二氧化碳激光消融治疗。术后并发症极少，大多数伤口在6周内愈合。该系列中53例IIIa期疾病患者中，共有34例在确诊后的第一年内通过四次或更少次数的激光消融得到控制。该技术为美法仑热灌注隔离肢体提供了一种简单有效的替代方法。激光治疗无法控制病情的患者可考虑进行隔离肢体灌注。
