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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Salgueiro-Pagadigorria C L, Constantin J, Bracht A, Nascimento E A, Ishii-Iwamoto E L

Department of Biochemistry, University of Maringá, Brazil.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Jan;113(1):93-8. doi: 10.1016/0742-8413(96)02041-5.

The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories. 2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats. 3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). 4. Gluconeogenesis from lactate plus pyruvate was inhibited. 5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside. 6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria. 7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs.

研究了非甾体非羧酸抗炎药吡罗昔康对离体灌注大鼠肝脏代谢的作用。主要目的是验证吡罗昔康是否也对糖原分解和能量代谢有活性，正如几种羧酸类非甾体抗炎药所表现的那样。2. 吡罗昔康增加了喂食和禁食大鼠肝脏的耗氧量。3. 吡罗昔康增加了内源性糖原的葡萄糖释放和糖酵解（糖原分解）。4. 乳酸加丙酮酸的糖异生受到抑制。5. 吡罗昔康对耗氧量的作用被抗霉素A阻断，但不被苍术苷阻断。6. 吡罗昔康在灌注大鼠肝脏代谢中的作用似乎是其对线粒体作用的结果。7. 可以得出结论，能量代谢的抑制和糖原分解的刺激并非羧酸类非甾体抗炎药的特异性特性。

Salgueiro-Pagadigorria C L, Constantin J, Bracht A, Nascimento E A, Ishii-Iwamoto E L

Department of Biochemistry, University of Maringá, Brazil.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Jan;113(1):93-8. doi: 10.1016/0742-8413(96)02041-5.

The actions of piroxicam, a nonsteroidal and noncarboxylic anti-inflammatory drug, on the metabolism of the isolated perfused rat liver were investigated. The main purpose was to verify if piroxicam is also active on glycogenolysis and energy metabolism, as demonstrated for several carboxylic nonsteroidal anti-inflammatories. 2. Piroxicam increased oxygen consumption in livers from both fed and fasted rats. 3. Piroxicam increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). 4. Gluconeogenesis from lactate plus pyruvate was inhibited. 5. The action of piroxicam on oxygen consumption was blocked by antimycin A, but not by atractyloside. 6. The action of piroxicam in the perfused rat liver metabolism seems to be a consequence of its action on mitochondria. 7. It can be concluded that inhibition of energy metabolism and stimulation of glycogenolysis are not specific properties of carboxylic nonsteroidal anti-inflammatory drugs.

研究了非甾体非羧酸抗炎药吡罗昔康对离体灌注大鼠肝脏代谢的作用。主要目的是验证吡罗昔康是否也对糖原分解和能量代谢有活性，正如几种羧酸类非甾体抗炎药所表现的那样。2. 吡罗昔康增加了喂食和禁食大鼠肝脏的耗氧量。3. 吡罗昔康增加了内源性糖原的葡萄糖释放和糖酵解（糖原分解）。4. 乳酸加丙酮酸的糖异生受到抑制。5. 吡罗昔康对耗氧量的作用被抗霉素A阻断，但不被苍术苷阻断。6. 吡罗昔康在灌注大鼠肝脏代谢中的作用似乎是其对线粒体作用的结果。7. 可以得出结论，能量代谢的抑制和糖原分解的刺激并非羧酸类非甾体抗炎药的特异性特性。