Yamaguchi K, Komori T, Hirose K, Tanabe H
Department of Neurology, Tokyo Metropolitan Neurological Hospital.
Rinsho Shinkeigaku. 1995 Aug;35(8):908-10.
In the nerve conduction study (NCS), the complex repetitive discharge (CRD) which follows M wave is occasionally observed. To understand the origin of CRD, we clinically analyzed the cases with CRD. Among the 1,580 cases examined by NCS, 13 (0.82%) cases including 6 of myotonic dystrophies (MyD), 2 of carpal tunnel syndrome and a case of multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, compression fracture of a lumbar vertebra, myasthenia gravis (MG) or Isaacs' syndrome had CRD. CRD was divided into forms; one consisted of an attenuating train of the complex of muscle potentials (muscular form) and the other one formed a simple repetition of single motor unit action potential (neural form). MyD, MG, and Isaacs' syndrome showed muscular form, and the others neural form. The pathophysiology of CRD was considered from the sites of lesions of nerve terminals, neuromuscular junctions, or muscle fibers and that the neural form might result from the axonal regeneration of peripheral motor nerve fibers.
在神经传导研究（NCS）中，偶尔会观察到跟随M波出现的复合重复放电（CRD）。为了了解CRD的起源，我们对出现CRD的病例进行了临床分析。在1580例接受NCS检查的病例中，有13例（0.82%）出现了CRD，其中包括6例强直性肌营养不良（MyD）、2例腕管综合征以及1例多发性硬化症、慢性炎症性脱髓鞘性多发性神经根神经病、腰椎压缩性骨折、重症肌无力（MG）或艾萨克斯综合征患者。CRD分为两种形式；一种由肌肉电位复合体的衰减序列组成（肌肉型），另一种由单个运动单位动作电位的简单重复组成（神经型）。MyD、MG和艾萨克斯综合征表现为肌肉型，其他则为神经型。我们从神经末梢、神经肌肉接头或肌纤维的病变部位对CRD的病理生理学进行了思考，认为神经型可能是由周围运动神经纤维的轴突再生引起的。
