Lee E J
Department of Pharmacology, National University of Singapore, Kent Ridge.
Eur J Clin Pharmacol. 1995;49(3):173-5. doi: 10.1007/BF00192376.
Many individuals possess an allele of the angiotensin I-converting enzyme (ACE) gene, which contains an extra 287-kb fragment in intron 16 (Rigat et al. 1992). Although the functionality of this fragment is at present unclear, the absence (deletion, D) or presence (insertion, I) of this fragment appears to be related to both the amount and activity of circulating ACE. This paper reports the possible polymorphic response of ACE to the ACE inhibitor enalaprilat in 54 normal Chinese subjects that is independent of the I/D polymorphism. The kinetics of ACE inhibition with enalaprilat was studied in serum from 54 normal Chinese subjects. Enalaprilat appKi ranged between 0.46 and 2.16 nM. An antimode was observed at 1.4 nM. Four subjects could be characterized as being poor responders to enalaprilat.
许多个体拥有血管紧张素I转换酶（ACE）基因的一个等位基因，该基因在第16内含子中含有一个额外的287 kb片段（Rigat等人，1992年）。尽管目前尚不清楚该片段的功能，但该片段的缺失（缺失型，D）或存在（插入型，I）似乎与循环ACE的量和活性都有关。本文报道了54名正常中国受试者中ACE对ACE抑制剂依那普利拉可能存在的多态性反应，且该反应与I/D多态性无关。在54名正常中国受试者的血清中研究了依那普利拉抑制ACE的动力学。依那普利拉的表观抑制常数（appKi）范围在0.46至2.16 nM之间。在1.4 nM处观察到一个反众数。四名受试者可被表征为对依那普利拉反应较差。
