Sato Y, Endo K, Ishikawa S, Onizuka M, Mitsui K, Mitsui T
Department of Surgery, Hitachi General Hospital, Ibaraki, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1996 Apr;44(4):524-8.
The relationship between bullous pemphigoid and malignancies of visceral organs is still controversial. A case of lung cancer associated with bullous pemphigoid is reported. A 63-year-old man admitted hospital because of multiple bullae of the whole body skin and continuous fever. The skin lesions were diagnosed as bullous pemphigoid by the skin biopsy. However, the chest x-ray on admission revealed a large tumor in the left upper lung field. The tumor was diagnosed as a lung cancer by trans-bronchial lung biopsy. The fever withdrew with the administration of prednisolone. The left upper lobectomy of the lung and mediastinal lymph node dissection were performed. The skin lesion disappeared 5 days after the surgery. This clinical course is thought to indicate the relationship of both diseases. Bullous pemphigoid is thought to have many problems during perioperative period, such as hypoproteinemia and delayed wound healing due to administration of the steroid, therefore intensive care is necessary in the perioperative care.
大疱性类天疱疮与内脏器官恶性肿瘤之间的关系仍存在争议。本文报道了一例与大疱性类天疱疮相关的肺癌病例。一名63岁男性因全身皮肤出现多个水疱及持续发热入院。经皮肤活检，皮肤病变被诊断为大疱性类天疱疮。然而，入院时胸部X线检查显示左上肺野有一个大肿瘤。经支气管肺活检，该肿瘤被诊断为肺癌。使用泼尼松龙后发热消退。进行了左肺上叶切除术及纵隔淋巴结清扫术。术后5天皮肤病变消失。该临床过程被认为表明了两种疾病之间的关系。大疱性类天疱疮在围手术期被认为有许多问题，如低蛋白血症以及因使用类固醇导致伤口愈合延迟，因此围手术期护理需要重症监护。
