Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood.
作者信息
Holt P G
机构信息
Division of Cell Biology, TVW Telethon Institute for Child Health Research, West Perth, Western Australia.
出版信息
J Exp Med. 1996 Apr 1;183(4):1297-301. doi: 10.1084/jem.183.4.1297.
Abstract
摘要
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本文引用的文献
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Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity.新生儿期肽暴露可使T细胞致敏，并在随后免疫时诱导其免疫偏离：对抗体介导与T细胞介导的自身免疫的影响。
J Exp Med. 1996 Apr 1;183(4):1613-21. doi: 10.1084/jem.183.4.1613.
2
Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium.在近100%的特应性个体和正常个体中均可检测到吸入性变应原特异性T细胞反应性：无血清培养基可揭示隐蔽反应。
Clin Exp Allergy. 1995 Jul;25(7):634-42. doi: 10.1111/j.1365-2222.1995.tb01111.x.
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The functional affinities of antibodies of different IgG subclasses to dietary antigens in mothers and their babies.母亲及其婴儿体内不同IgG亚类抗体对膳食抗原的功能亲和力。
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Appearance of IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children.
Pediatr Allergy Immunol. 1993 Nov;4(4):182-6. doi: 10.1111/j.1399-3038.1993.tb00089.x.
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Aeroallergen sensitization can occur during fetal life.
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The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.对吸入性可溶性蛋白质抗原的天然免疫反应涉及主要组织相容性复合体（MHC）I类限制的CD8 + T细胞介导但MHC II类限制的CD4 + T细胞依赖性免疫偏离，从而导致免疫球蛋白E产生的选择性抑制。
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Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema?
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Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.口服耐受后无反应性或主动抑制的诱导取决于抗原剂量。
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Immunoprophylaxis of atopy: light at the end of the tunnel?特应性疾病的免疫预防：曙光在望？
Immunol Today. 1994 Oct;15(10):484-9. doi: 10.1016/0167-5699(94)90194-5.
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