通过动态氟代脱氧葡萄糖正电子发射断层扫描术确定阿尔茨海默病中葡萄糖转运和磷酸化的减少。

Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET.

作者信息

Piert M, Koeppe R A, Giordani B, Berent S, Kuhl D E

机构信息

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA.

出版信息

J Nucl Med. 1996 Feb;37(2):201-8.

PMID:8667045

Abstract

UNLABELLED

Using dynamic [18F]fluorodeoxyglucose (FDG) and PET, kinetic rate constants that describe influx (K1) and efflux (k2) of FDG as well as phosphorylation (k3) and dephosphorylation (k4) were determined in patients with probable Alzheimer's disease and similarly aged normal controls.

METHODS

The regional cerebral metabolic rate for glucose (CMRglu) was calculated from individually fitted rate constants in frontal, temporal, parietal and occipital cerebral cortex, caudate nucleus, putamen, thalamus and cerebellar cortex. Dynamic PET scans were obtained in normal controls (n = 10, mean age = 67) and Alzheimer's disease patients (n = 8, mean age = 67) for 60 min following injection of 10 mCi of FDG.

RESULTS

The Alzheimer's disease group was characterized by decreases of the CMRglu ranging from 13.3% in the frontal to 40.9% in the parietal cortex, which achieved significance in all regions except the thalamus. K1 was significantly reduced in the parietal (p < 0.01) and temporal cortices (p < 0.05). Significant declines in k3 were found in the parietal (p < 0.005), temporal and occipital cortex, and in the putamen and cerebellum (p < 0.05). The rate constants k2 and k4 were unchanged in the Alzheimer's disease group.

CONCLUSION

These data suggest that hypometabolism in Alzheimer's disease is related to reduced glucose phosphorylation activity as well as diminished glucose transport, particularly in the most metabolically affected areas of the brain, the parietal and temporal cortex.

摘要

未标注

使用动态[18F]氟脱氧葡萄糖（FDG）和正电子发射断层扫描（PET），在可能患有阿尔茨海默病的患者以及年龄相仿的正常对照者中，测定了描述FDG流入（K1）和流出（k2）以及磷酸化（k3）和去磷酸化（k4）的动力学速率常数。

方法

根据额叶、颞叶、顶叶和枕叶大脑皮质、尾状核、壳核、丘脑和小脑皮质中各自拟合的速率常数，计算局部脑葡萄糖代谢率（CMRglu）。在10名正常对照者（平均年龄 = 67岁）和8名阿尔茨海默病患者（平均年龄 = 67岁）中，静脉注射10毫居里FDG后进行60分钟的动态PET扫描。

结果

阿尔茨海默病组的特征是CMRglu降低，范围从额叶的13.3%到顶叶皮质的40.9%，除丘脑外，所有区域均有显著降低。顶叶（p < 0.01）和颞叶皮质（p < 0.05）的K1显著降低。在顶叶（p < 0.005）、颞叶和枕叶皮质以及壳核和小脑中发现k3显著下降（p < 0.05）。阿尔茨海默病组的速率常数k2和k4未发生变化。