Antos M, Trafny E A, Grzybowski J
Department of Microbiology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Pharmacol Res. 1995 Jul-Aug;32(1-2):85-7. doi: 10.1016/s1043-6618(95)80013-1.
The influence of liposomal amikacin on Pseudomonas aeruginosa was studied. P. aeruginosa clinical isolates caused release of encapsulated amikacin from liposomes. The liposomal amikacin proved to be active as bactericidal agent after 3 h of incubation with P. aeruginosa. Incubation of P. aeruginosa with liposomal amikacin resulted in inhibition of the growth when equivalent of 2 MIC was added but not when equivalent of 1 MIC was added. Susceptibility of bacterial isolates to the liposomal amikacin varied with bacterial strain used, but generally encapsulation of amikacin did not enhance their antibacterial activity.
研究了脂质体阿米卡星对铜绿假单胞菌的影响。铜绿假单胞菌临床分离株可导致脂质体中包裹的阿米卡星释放。脂质体阿米卡星在与铜绿假单胞菌孵育3小时后被证明具有杀菌活性。当加入相当于2倍最小抑菌浓度（MIC）的脂质体阿米卡星与铜绿假单胞菌孵育时，可抑制其生长，但加入相当于1倍MIC时则无此效果。细菌分离株对脂质体阿米卡星的敏感性因所用菌株而异，但总体而言，阿米卡星的包裹并未增强其抗菌活性。
