Antibacterial activity of liposomal amikacin against Pseudomonas aeruginosa in vitro.

The influence of liposomal amikacin on Pseudomonas aeruginosa was studied. P. aeruginosa clinical isolates caused release of encapsulated amikacin from liposomes. The liposomal amikacin proved to be active as bactericidal agent after 3 h of incubation with P. aeruginosa. Incubation of P. aeruginosa with liposomal amikacin resulted in inhibition of the growth when equivalent of 2 MIC was added but not when equivalent of 1 MIC was added. Susceptibility of bacterial isolates to the liposomal amikacin varied with bacterial strain used, but generally encapsulation of amikacin did not enhance their antibacterial activity.