Angulo A, Ghazal P
Department of Immunology, Scripps Research Institute, La Jolla, California, USA.
Scand J Infect Dis Suppl. 1995;99:113-5.
Human cytomegalovirus (HCMV) may opportunistically use retinoic acid (RA), a physiologically essential control molecule of cellular differentiation, to advance its own replication. At present, it is not clear whether RA stimulation of HCMV replication is exclusively a differentiation driven event. We report that exposure of permissively infected primary human foreskin fibroblast cells to RA transcriptionally activates the viral major immediate-early promoter (MIEP) and enhances the production of infectious particles. These experiments implicate a direct involvement of RA in modulating HCMV activation.
人巨细胞病毒（HCMV）可能会伺机利用视黄酸（RA）——一种细胞分化过程中生理必需的调控分子——来促进自身复制。目前尚不清楚RA对HCMV复制的刺激是否完全是由分化驱动的事件。我们报告称，将允许性感染的原代人包皮成纤维细胞暴露于RA中会转录激活病毒主要立即早期启动子（MIEP），并增强感染性颗粒的产生。这些实验表明RA直接参与调节HCMV的激活。
