Ballo M S, Silverberg S G, Sidawy M K
Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA.
Acta Cytol. 1996 May-Jun;40(3):536-40. doi: 10.1159/000333911.
To evaluate the cytologic features of villoglandular adenocarcinoma of the cervix in cervical smears.
Eleven cervical smears from six patients with histologically proven villoglandular adenocarcinoma were reviewed.
All smears were positive for tumor upon retrospective evaluation and revealed similar cytologic features. The tumor cells were abundant and were shed in sheets, tight clusters and tissue fragments. Papillary projections, clusters with smooth borders and flattened cells at the periphery, strips with peripheral nuclear palisading and pseudostratification, and rosettes were present. Nuclear crowding and overlapping were prominent. The nuclei were small, ovoid and hyperchromatic. The chromatin was granular and evenly distributed. Nucleoli were absent or inconspicuous. Mitoses were present.
VGA may cause diagnostic difficulty because it shares some morphologic similarities with adenocarcinoma in situ, squamous cell carcinoma in situ involving endocervical glands, endometrial cells directly sampled with the Cytobrush and reactive endocervical cells. However, the above constellation of features should permit a cytologic diagnosis.
评估宫颈涂片检查中宫颈绒毛腺管状腺癌的细胞学特征。
回顾了6例经组织学证实为绒毛腺管状腺癌患者的11份宫颈涂片。
经回顾性评估，所有涂片肿瘤均呈阳性，并显示出相似的细胞学特征。肿瘤细胞丰富，呈片状、紧密团块及组织碎片脱落。可见乳头样突起、边界光滑的团块且周边细胞扁平、周边核呈栅栏状排列及假复层的条带，以及玫瑰花结。核拥挤和重叠明显。细胞核小，呈卵圆形，染色质深染。染色质呈颗粒状且分布均匀。无核仁或核仁不明显。可见有丝分裂。
绒毛腺管状腺癌可能会造成诊断困难，因为它与原位腺癌、累及宫颈管腺体的原位鳞状细胞癌、用细胞刷直接取材的子宫内膜细胞及宫颈反应性细胞在形态学上有一些相似之处。然而，上述一系列特征应有助于进行细胞学诊断。
