Hernández E R, Seco-Durban C, Revilla M, González-Riola J, Rico H
Departamento de Medicina, Universidad de Alcalá de Henares, Madrid, Spain.
Age Ageing. 1995 Sep;24(5):447-50. doi: 10.1093/ageing/24.5.447.
We compared bone mass in premenopausal, perimenopausal, and postmenopausal women using peripheral quantitative computed tomography to measure separately cortical, trabecular, and total bone density. Trabecular bone density was lower (p < 0.05) in the perimenopausal women than in the healthy premenopausal women. In perimenopausal women, trabecular bone density showed a significant linear regression with age (r = 0.554, p < 0.001), but cortical bone density did not (r = 0.130, p = 0.447). The group of postmenopausal women had significantly lower bone mass in all three bone compartments than the premenopausal and perimenopausal women. These findings confirm the existence of a significant loss of trabecular bone mass in the perimenopausal period.
我们使用外周定量计算机断层扫描分别测量皮质骨、小梁骨和总骨密度，比较了绝经前、围绝经期和绝经后女性的骨量。围绝经期女性的小梁骨密度低于健康的绝经前女性（p < 0.05）。在围绝经期女性中，小梁骨密度与年龄呈显著线性回归（r = 0.554，p < 0.001），但皮质骨密度未呈现这种关系（r = 0.130，p = 0.447）。绝经后女性组在所有三个骨腔室中的骨量均显著低于绝经前和围绝经期女性。这些发现证实了围绝经期存在显著的小梁骨量丢失。
