Caprio S, Hyman L D, McCarthy S, Lange R, Bronson M, Tamborlane W V
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
Am J Clin Nutr. 1996 Jul;64(1):12-7. doi: 10.1093/ajcn/64.1.12.
The regional distribution of body fat has repeatedly been found to be a significant and independent risk factor for cardiovascular disease in both obese men and women. To determine whether abnormalities in the lipid-lipoprotein profile and systolic and diastolic blood pressure are related to specific fat depots early in the course of obesity, we used magnetic resonance imaging to measure accurately intraabdominal and subcutaneous fat masses in 14 obese [body mass index (BMI; in kg/m2) 30 +/- 1.3] and 10 nonobese (BMI: 21 +/- 0.5) adolescent girls matched for age and Tanner stage of development. Intraabdominal and subcutaneous fat depots were two- to threefold greater in obese than in nonobese girls (P < 0.01). Total cholesterol, triacylglycerol, low-density-lipoprotein (LDL) cholesterol, basal insulin, and systolic and diastolic blood pressure were significantly higher in obese adolescent girls than in control subjects. In obese girls, intraabdominal fat but not BMI or waist-to-hip ratio was highly correlated with basal insulin (r = 0.55, P < 0.04), triacylglycerols (r = 0.53, P < 0.03), and high-density-lipoprotein (HDL) cholesterol (r = -0.54, P < 0.04). Femoral adipose tissue was inversely related to triacylglycerol (r = -0.51) and LDL cholesterol (r = -0.56, P < 0.05) concentrations in obese girls. The study indicates that early in the natural history of obese adolescent girls, cardiovascular risk factors are related to the amount of intraabdominal fat.
人们反复发现，无论肥胖男性还是女性，体内脂肪的区域分布都是心血管疾病的一个重要且独立的危险因素。为了确定肥胖早期脂质 - 脂蛋白谱以及收缩压和舒张压的异常是否与特定的脂肪储存部位有关，我们使用磁共振成像技术准确测量了14名肥胖（体重指数[BMI；单位：kg/m²] 30±1.3）和10名非肥胖（BMI：21±0.5）的青春期女孩的腹内脂肪和皮下脂肪量，这些女孩在年龄和坦纳发育阶段上相匹配。肥胖女孩的腹内和皮下脂肪储存量比非肥胖女孩大两到三倍（P<0.01）。肥胖青春期女孩的总胆固醇、三酰甘油、低密度脂蛋白（LDL）胆固醇、基础胰岛素以及收缩压和舒张压均显著高于对照组。在肥胖女孩中，腹内脂肪而非BMI或腰臀比与基础胰岛素（r = 0.55，P<0.04）、三酰甘油（r = 0.53，P<0.03）和高密度脂蛋白（HDL）胆固醇（r = -0.54，P<0.04）高度相关。在肥胖女孩中，股部脂肪组织与三酰甘油（r = -0.51）和LDL胆固醇（r = -0.56，P<0.05）浓度呈负相关。该研究表明，在肥胖青春期女孩的自然病程早期，心血管危险因素与腹内脂肪量有关。
